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Electron Microscopy of Human Bronchial Mucosa

Geoffrey L. Brinkman, MD; John H. L. Watson, PhD
JAMA. 1965;192(9):760-762. doi:10.1001/jama.1965.03080220024005.
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Whereasg visible light in conjunction with optical staining techniques is useful for studying structures as small as 1,500 Angstrom units (1 A =0.0001α, 1α=0.0001 cm) in biological tissues, or light microscopy using ultraviolet radiation is useful for structures as small as 1,000 A units, electron microscopy, because of its higher resolution in conjunction with heavy metal staining, permits visualization of dimensions as small as 5 A units. Thus, in cytology the electron microscopy is capable of demonstrating the tiniest intercellular structures, the ultrafine structure of the cell walls and membranes and indeed, of reaching down into the molecular level itself. This power of the electron microscope must be used with caution insofar as interpretation of a whole organ is concerned because of the extremely minute areas of tissue which it examines in any single field. Also, because the internal cellular structure is seen in such detail, changes due to autolysis,


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