SYSTEMIC CRYPTOCOCCOSIS (torulosis) is not as rare as was once believed. There were 286 cases reported in the English literature alone between 1950 and 1960.1 Infection with Cryptococcus neoformans is most often associated with hematologic malignancies, steroid therapy, sarcoidosis, diabetes mellitus, tuberculosis, rheumatoid disease, cirrhosis, or some other debilitating illness. It usually involves the central nervous system. Although the lungs, skin, bones, adrenals, kidneys, and occasionally other organs have been affected, involvement of the prostate has been rarely observed. This report deals with a patient in whom cryptococcosis was diagnosed early by histological and bacteriological study of the prostate gland.
Report of a Case
This 31-year-old white man had Hodgkin's disease diagnosed by lymph node biopsy in 1956. Over the ensuing seven years, he was treated with x-radiation to all nodebearing areas, mechlorethamine hydrochloride, cyclophosphamide, Elderfield pyrimidine mustard, vinblastine sulfate, and hexamethylmelamine. In 1959, an acquired spherocytic hemolytic anemia