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Carbarsone Toxicity

Chauncey D. Leake, PhD
JAMA. 1965;192(1):63. doi:10.1001/jama.1965.03080140069024.
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To the Editor:—  It is interesting to have the report of carbarsone toxicity from Drs. H. J. Schwartz and H. Y. Donnenfeld (letters, JAMA191:678 [Feb 22] 1965). Toxic reactions to carbarsone have fortunately been few, in spite of the long-continued use of carbarsone for the treatment of amebiasis.It would appear that the cases reported by Schwartz and Donnenfeld were clearly due to overdosage. When we introduced carbarsone for the treatment of amebiasis (JAMA99:195-199 [Jan 16] 1932), we recommended that the dosage be 75 mg/kg of body weight in divided amounts over at least a ten-day period. We said: "Practically, this dosage amounts in the average adult to 0.25 gm twice daily for ten days." We cautioned specifically against using carbarsone in amoebic hepatitis, or in amounts that might cause symptoms or arsenic toxicity. We reported the minimal single lethal doses of carbarsone administered orally to


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