The Spectrum of Cholestatic Hepatic Disease

Maurice H. Stauffer; William G. Sauer, MD; William H. Dearing, MD; Archie H. Baggenstoss, MD
JAMA. 1965;191(10):829-837. doi:10.1001/jama.1965.03080100047011.
Text Size: A A A
Published online

Hepatic disease has long been a well-documented but rare complication of chronic ulcerative colitis. Early reports, mainly from necropsy studies, showed the hepatic lesions most frequently to be either fatty liver or some form of cirrhosis. During the past 12 years, there have been two important changes in the study of this relationship: (1) increased recognition that liver-function tests give abnormal results in many patients with chronic ulcerative colitis,1 and (2) increased observation of patients with prolonged hepatic injury characterized by cholestatic features. In some of these patients the lesion progresses to cirrhosis, often exhibiting clinical and laboratory characteristics of the "biliary" type.1-3

Two reports in 19521,4 initiated a changing concept in identifying the hepatic lesions seen with ulcerative colitis. Kleckner and co-workers1 reported on patients with ulcerative colitis and chronic jaundice, "pericholangitis with bile stasis" noted on hepatic biopsy, and clinical and laboratory data suggesting a


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.