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Carl Kupfer, MD
JAMA. 1965;191(7):592. doi:10.1001/jama.1965.03080070076011.
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Elsewhere in this issue (p 526) Cowan calls attention to the need for the general practitioner and the internist to question every patient about a family history of glaucoma and to use the tonometer routinely for measuring intraocular pressure. Cowan indicates that among children, siblings, and parents of patients with open-angle glaucoma, the incidence of glaucoma or borderline glaucoma was 6.6%, which is three times the expected rate among the general population. He might have added also that about 50% of all direct offspring of patients with open-angle glaucoma have suspected glaucoma, on the basis of a positive water-drinking test.1 Just as corticosteroids can provoke an abnormal glucose tolerance curve in patients having no evidence of diabetes, topically applied corticosteroids provoke an elevation of intraocular pressure in about one quarter of the normal population not having a parent with open-angle glaucoma. However, topical corticosteroids will induce an intraocular pressure


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