Eradication of tuberculosis, the theme of the Arden House Conference in 1959, is a formidable project with limited chances of success in this century. Yet the shift in emphasis from control to eradication gives truth to the realization that present measures are containing but not effectively reducing the problem. With modern therapy, chances are good that with early detection, sufficient treatment, and thorough follow-up the disease will not later become reactivated nor the patient be a source of infection for others. Epidemiology is so much a key to eradication of tuberculosis that failure to use its techniques should be likened to withholding of therapy. We should expect of epidemiology in the future what was hoped for pharmacology in the past. But since we must work with today's imperfections, it would be well to review what some of these imperfections are.
Failure of Detection and Reporting.—
Simpson and Lowell1 have