Removal of the distal 75% of the pancreas may be done in adults without producing diabetes or deficiency of external pancreatic secretion. This procedure is often employed in the treatment of malignant and benign tumors. Resection of the body and tail of the pancreas may also be useful in treatment of an occasional patient who sustains severe trauma to the pancreas with complete transection, or with a crushing injury involving the distal portion of this organ. Little data are available, however, concerning the effect of extensive pancreatic resection upon the young, growing individual. Although such a procedure does not result in the development of diabetes, the quantitative requirements for exocrine secretion during the phase of rapid growth have not been established. This experiment was designed to evaluate the effect of distal subtotal pancreatectomy on the growth and metabolism of young mice.
Material and Methods
Ninety C-3-H mice, each 4 weeks