Author Contributions: Dr Wang had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Wang, Ting.
Acquisition of data: Li, Peterson.
Analysis and interpretation of data: Wang, Nallamothu, Krumholz, Li, Roe, Jollis, Jacobs, Holmes, Peterson, Ting.
Drafting of the manuscript: Wang, Nallamothu, Krumholz, Peterson, Ting.
Critical revision of the manuscript for important intellectual content: Wang, Nallamothu, Krumholz, Li, Roe, Jollis, Jacobs, Holmes, Peterson, Ting.
Statistical analysis: Li.
Obtained funding: Peterson.
Study supervision: Peterson, Ting.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. All conflicts of interest are listed at http://www.dcri.org. Dr Wang reports receiving research grants to the Duke Clinical Research Institute from the Bristol-Myers Squibb/Sanofi Partnership, Schering Plough/Merck, The Medicines Co, Heartscape, Canyon Pharmaceuticals, and Eli Lilly/Daiichi Sankyo Alliance, as well as consulting fees/honoraria for Medco and Astra Zeneca. Dr Krumholz reports chairing a scientific advisory board for United Healthcare. Dr Roe reports receiving research funding from Eli Lilly, Novartis, Merck-Schering Plough, Bristol-Myers Squibb, the American College of Cardiology, and the American Heart Association; and consulting fees/honoraria from Glaxo Smith Kline, KAI Pharmaceuticals, Novartis, Eli Lilly, Bristol-Myers Squibb, Sanofi-Aventis, Orexigen, and Astra Zeneca. Dr Jacobs reports chairing the Mission: Lifeline Advisory Working Group. Dr Peterson reports receiving research grants from Bristol-Myers Squibb, Sanofi-Aventis, Eli Lilly, Schering Plough/Merck, and St Jude Inc and consultant fees from Bayer and Pfizer. No other disclosures were reported.
Funding/Support: This research was supported by the ACC Foundation's NCDR. The ACTION Registry-GWTG is an initiative of the ACC Foundation and the AHA with partnering support from the Society of Chest Pain Centers, the American College of Emergency Physicians, and the Society of Hospital Medicine. The registry is sponsored in part by the Bristol-Myers Squibb/Sanofi Partnership.
Role of the Sponsors: The study's sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: Dr Peterson, a contributing editor for JAMA, was not involved in the editorial review of or decision to publish this article. The views expressed in this article represent those of the authors and do not necessarily represent the official views of the NCDR or its associated professional societies identified at http://www.ncdr.com.
Additional Contributions: We thank Erin LoFrese, BA, Duke Clinical Research Institute, for editorial assistance. Ms LoFrese did not receive compensation for her assistance apart from her employment at Duke Clinical Research Institute.