Author Contributions: Dr Solomon had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Solomon, Schneeweiss.
Acquisition of data: Solomon.
Analysis and interpretation of data: Solomon, Massarotti, Garg, Liu, Canning, Schneeweiss.
Drafting of the manuscript: Solomon, Schneeweiss.
Critical revision of the manuscript for important intellectual content: Solomon, Massarotti, Garg, Liu, Canning, Schneeweiss.
Statistical analysis: Solomon, Liu, Canning, Schneeweiss.
Obtained funding: Solomon.
Administrative, technical, or material support: Solomon, Massarotti.
Study supervision: Solomon, Schneeweiss.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Solomon reports having received support through a research grant from Abbott, directing an educational course supported by Bristol-Myers Squibb, and serving in an unpaid role on 2 Pfizer-sponsored trials. Dr Massarotti reports being a clinical investigator for an RA therapeutics trial sponsored by Bristol-Myers Squibb, and for 2 sponsored systemic lupus erythematosus trials, 1 funded by EMD-Serono, and the second as part of the Autoimmune Centers of Excellence through the National Institutes of Health; and receiving consulting fees from UCB, Human Genome Sciences, Pfizer, Ampimmune, and Policy Analysis Inc. Dr Garg (or spouse) reports having received consultant fees from sanofi-aventis, Pfizer, Novartis, Biogen Idec, Teva, and EMD Serono. Dr Schneeweiss is principal investigator of the Brigham and Women's Hospital DEcIDE Center on Comparative Effectiveness Research and the DEcIDE Methods Center both funded by Agency for Healthcare Research and Quality and of the Harvard-Brigham Drug Safety and Risk Management Research Center funded by the FDA. Dr Schneeweiss reports being a paid member of the scientific advisory board of HealthCore; a consultant to HealthCore and WHISCON; and a recipient of investigator-initiated grants from Pfizer and Novartis.
Funding/Support: This research was supported by an investigator-initiated research grant to Dr Solomon from Amgen.
Role of the Sponsor: Amgen paid for the research through a research contract with the Brigham and Women's Hospital. Amgen reviewed the study protocol and reviewed a draft manuscript but had no editorial control.