Author Contributions: Dr Ray had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Preiss and Seshasai are joint first authors, and Drs Sattar and Ray are joint senior authors.
Study concept and design: Preiss, Seshasai, Welsh, Sattar, Ray.
Acquisition of data: Murphy, Waters, DeMicco, Barter, Cannon, Braunwald, Lemos, Blazing, Pedersen, Tikkanen, Ray.
Analysis and interpretation of data: Preiss, Seshasai, Welsh, Murphy, Ho, Waters, Cannon, Sabatine, Kastelein, Pedersen, Tikkanen, Sattar, Ray.
Drafting of the manuscript: Preiss, Seshasai, Welsh, Sattar, Ray.
Critical revision of the manuscript for important intellectual content: Preiss, Seshasai, Murphy, Ho, Waters, DeMicco, Barter, Cannon, Sabatine, Braunwald, Kastelein, Lemos, Blazing, Pedersen, Tikkanen, Sattar, Ray.
Statistical analysis: Seshasai, Preiss, Murphy, Ray.
Administrative, technical, or material support: DeMicco, Braunwald, Kastelein, Blazing, Tikkanen.
Study supervision: Welsh, Cannon, Kastelein, Sattar, Ray.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Ms Murphy reported receiving research grant support through the TIMI Study Group from Bristol-Myers Squibb and Merck. Dr Ho reported receiving consulting fees from Pfizer. Dr Waters reported receiving honoraria for lectures from Bristol-Myers Squibb and Pfizer and consulting for Merck Schering Plough and Pfizer for participation in clinical trial committees. Dr DeMicco reported being an employee of Pfizer. Dr Barter reported acting as member on advisory boards for AstraZeneca, CSL, Merck, Novartis, Pfizer, and Roche; receiving honoraria from Abbott, AstraZeneca, Merck, Novartis, Pfizer, and Roche; and participating in clinical trials sponsored by AstraZeneca, Merck, Pfizer, and Roche. Dr Cannon reported receiving research grants or support from Accumetrics, AstraZeneca, GlaxoSmithKline, Intekrin Therapeutics, Merck, and Takeda; acting on advisory boards (funds donated to charity) for Alnylam, Bristol-Myers Squibb/sanofi, and Novartis; receiving honoraria for independent educational symposia from AstraZeneca and Pfizer; and acting as a clinical advisor with equity for Automedics Medical Systems. Dr Sabatine reported receiving research grant support through Brigham and Women's Hospital from AstraZeneca, Bristol-Myers Squibb/sanofi-aventis, Schering Plough, and Amgen; consulting for AstraZeneca and Bristol-Myers Squibb/sanofi-aventis; and lecturing for Bristol-Myers Squibb/sanofi-aventis. Dr Braunwald reported receiving research support for the TIMI Study Group from Merck, AstraZeneca, and Pfizer. Dr Kastelein reported having participated in clinical trials sponsored by Pfizer, AstraZeneca, Merck, Eli Lilly, sanofi-aventis, Roche, Novartis, Boehringer Ingelheim, Isis, and Genzyme and receiving lecturing and consulting fees from Pfizer, AstraZeneca, Merck, Eli Lilly, sanofi-aventis, Roche, Novartis, Isis, Genzyme, and Kowa. Dr de Lemos reported consulting for AstraZeneca and receiving honoraria from Merck/Schering and Pfizer for lectures (>2 years ago). Dr Blazing reported receiving speaking or consulting fees from Merck and being the principal investigator on a research grant from Schering-Plough administered through the Duke Clinical Research Institute. Dr Pedersen reported receiving speakers' honoraria from and consulting for Pfizer and Merck-Schering Plough and receiving speakers' honoraria from AstraZeneca. Dr Tikkanen reported participating in clinical trials sponsored by Pfizer and Takeda, acting as member of a steering committee for a trial sponsored by Pfizer, and being a member of an advisory board of MSD Finland. Dr Sattar reported consulting for and receiving lecture fees from Merck, Pfizer, and AstraZeneca and having received research grant support from Pfizer. Dr Ray reported consulting/lecturing at symposia funded by Novo Nordisk, Roche, Pfizer, Merck, sanofi-aventis, and AstraZeneca. No other disclosures were reported.
Additional Contributions: Unpublished data for these analyses were provided to the corresponding authors by the SEARCH Collaborative Group.