Each year, thousands of individuals in the United States enroll in phase 1 drug trials as healthy volunteers to earn money. Payments for participation range from a few hundred to a few thousand dollars.1 Some individuals have enrolled in as many as 80 phase 1 studies.2 Professional research participants have developed their own social networks, Web pages, associations, and publications, which they use to learn about new studies, share information and experiences, and understand the ethical, regulatory, and scientific aspects of clinical research.1 Some individuals pursue research participation as a full-time job and travel across the country enrolling in studies.1 One person claims he earned $32 000 in 2008.2
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