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Original Contribution |

Accuracy and Outcomes of Screening Mammography in Women With a Personal History of Early-Stage Breast Cancer FREE

Nehmat Houssami, MBBS, PhD; Linn A. Abraham, MS; Diana L. Miglioretti, PhD; Edward A. Sickles, MD; Karla Kerlikowske, MD; Diana S. M. Buist, PhD, MPH; Berta M. Geller, EdD; Hyman B. Muss, MD; Les Irwig, MBBCh, PhD
[+] Author Affiliations

Author Affiliations: Screening and Test Evaluation Program, School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia (Drs Houssami and Irwig); Biostatistics Unit, Group Health Research Institute, Seattle, Washington (Ms Abraham and Dr Miglioretti); Department of Biostatistics (Dr Miglioretti) and Group Health Research Institute and Departments of Epidemiology and Health Services (Dr Buist), University of Washington, Seattle; Department of Radiology (Dr Sickles) and Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs (Dr Kerlikowske), University of California, San Francisco; Departments of Family Medicine and Radiology, University of Vermont, Burlington (Dr Geller); and Department of Medicine, University of North Carolina, Chapel Hill (Dr Muss).


JAMA. 2011;305(8):790-799. doi:10.1001/jama.2011.188.
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Context Women with a personal history of breast cancer (PHBC) are at risk of developing another breast cancer and are recommended for screening mammography. Few high-quality data exist on screening performance in PHBC women.

Objective To examine the accuracy and outcomes of mammography screening in PHBC women relative to screening of similar women without PHBC.

Design and Setting Cohort of PHBC women, mammogram matched to non-PHBC women, screened through facilities (1996-2007) affiliated with the Breast Cancer Surveillance Consortium.

Participants There were 58 870 screening mammograms in 19 078 women with a history of early-stage (in situ or stage I-II invasive) breast cancer and 58 870 matched (breast density, age group, mammography year, and registry) screening mammograms in 55 315 non-PHBC women.

Main Outcome Measures Mammography accuracy based on final assessment, cancer detection rate, interval cancer rate, and stage at diagnosis.

Results Within 1 year after screening, 655 cancers were observed in PHBC women (499 invasive, 156 in situ) and 342 cancers (285 invasive, 57 in situ) in non-PHBC women. Screening accuracy and outcomes in PHBC relative to non-PHBC women were cancer rates of 10.5 per 1000 screens (95% CI, 9.7-11.3) vs 5.8 per 1000 screens (95% CI, 5.2-6.4), cancer detection rate of 6.8 per 1000 screens (95% CI, 6.2-7.5) vs 4.4 per 1000 screens (95% CI, 3.9-5.0), interval cancer rate of 3.6 per 1000 screens (95% CI, 3.2-4.1) vs 1.4 per 1000 screens (95% CI, 1.1-1.7), sensitivity 65.4% (95% CI, 61.5%-69.0%) vs 76.5% (95% CI, 71.7%-80.7%), specificity 98.3% (95% CI, 98.2%-98.4%) vs 99.0% (95% CI, 98.9%-99.1%), abnormal mammogram results in 2.3% (95% CI, 2.2%-2.5%) vs 1.4% (95% CI, 1.3%-1.5%) (all comparisons P < .001). Screening sensitivity in PHBC women was higher for detection of in situ cancer (78.7%; 95% CI, 71.4%-84.5%) than invasive cancer (61.1%; 95% CI, 56.6%-65.4%), P < .001; lower in the initial 5 years (60.2%; 95% CI, 54.7%-65.5%) than after 5 years from first cancer (70.8%; 95% CI, 65.4%-75.6%), P = .006; and was similar for detection of ipsilateral cancer (66.3%; 95% CI, 60.3%-71.8%) and contralateral cancer (66.1%; 95% CI, 60.9%-70.9%), P = .96. Screen-detected and interval cancers in women with and without PHBC were predominantly early stage.

Conclusion Mammography screening in PHBC women detects early-stage second breast cancers but has lower sensitivity and higher interval cancer rate, despite more evaluation and higher underlying cancer rate, relative to that in non-PHBC women.

The high prevalence of breast cancer survivors is due to general gains in life expectancy and to improved survival in women with a personal history of breast cancer (PHBC), attributable to improvements in local and systemic treatments and early detection. Women with PHBC are at risk of developing second breast cancers, which can be ipsilateral (in-breast recurrence or new ipsilateral cancer) or contralateral; risk of a second breast cancer was recently estimated at 5.4 to 6.6 per 1000 woman-years.1 The consensus is that PHBC women may benefit from early detection of second breast cancers, although evidence of screening benefit in these women comes from nonrandomized studies25 and extrapolation of benefit from randomized population mammography screening trials. Screening or surveillance mammography (referred to here as screening)1,6 is usually recommended by guidelines and consensus recommendations for follow-up of PHBC women.712

Several reviews have concluded that little quality evidence is available on mammography screening accuracy in PHBC women6,13,14; most studies are based on selected series, are limited to women who had second breast cancers or further breast surgery,3,6,1518 or use methods that do not allow estimation of specificity.6 Studies of screening in PHBC women predominantly report only the proportion of second cancers detected by mammography, in the range of 10% to 80%.6,13,14 Standard measures of screening performance in PHBC women, such as cancer detection rates or interval cancer rates for ipsilateral and contralateral cancers, are not available from screening programs. Furthermore, interest exists in using adjunct imaging such as higher-cost magnetic resonance imaging to screen PHBC women19,20 despite lack of reliable data on mammography screening in these women.

Valid estimates of the accuracy of screening mammography are therefore needed to guide clinical practice and policy in this setting and to inform clinicians and PHBC women of expected screening outcomes. This study examines the accuracy and outcomes of screening mammography and factors associated with screening outcomes in women with a PHBC who participated in mammography screening through facilities affiliated with the Breast Cancer Surveillance Consortium (BCSC). Context on screening mammography outcomes from the same practices in women of approximately population risk came from a comparison group with no reported breast cancer history and with a mammogram matched to PHBC women on breast density, age group, and mammography registry and year.

Setting

Participants were women receiving mammograms at facilities in 5 of the 7 mammography registries of the National Cancer Institute–funded BCSC, which collects demographic and mammography information from women undergoing mammography at participating community-based facilities. Each registry links data on screened women to their state or the Surveillance, Epidemiology, and End Results cancer registries to ascertain breast cancer diagnoses. Five registries collect both cancer registry and pathology outcomes data for complete capture of second cancers and were sources for this study: Carolina Mammography Registry (North Carolina), Group Health Breast Cancer Screening Project (Washington State), New Hampshire Mammography Network, New Mexico Mammography Project, and Vermont Breast Cancer Surveillance System. Information about the BCSC is available at http://breastscreening.cancer.gov/.

Each registry and the BCSC Statistical Coordinating Center received institutional review board approval for either active or passive consenting processes or a consent waiver to enroll women, link data, and perform analytic studies. All procedures are Health Insurance Portability and Accountability Act compliant, and all registries and the Statistical Coordinating Center received a federal certificate of confidentiality and other protection for identities of women, physicians, and facilities in this research.

Screening Examinations

Screening mammograms from 1996 to 2007 in PHBC women were identified. Women (44 509) with an initial early-stage breast cancer,1 including diagnoses of ductal carcinoma in situ or American Joint Committee on Cancer21 stage I to II invasive carcinoma, were eligible for inclusion. Cancer registry and pathology databases were used to ascertain whether a woman had a breast cancer diagnosis, the diagnosis date, and cancer characteristics. Excluded were women with bilateral mastectomy for first cancer. A mammogram performed at least 6 months after first breast cancer diagnosis was defined as screening if it was indicated as a routine screen by the radiologist or technologist, not within 9 months of a previous breast imaging examination, not a unilateral mammogram in a woman with breast-conserving surgery, and not from a woman self-reporting a lump or nipple discharge. Screening mammograms with at least 1 year of follow-up for ascertaining second cancer diagnoses were included. Women meeting the inclusion criteria and receiving at least 1 screening mammogram with a final Breast Imaging Reporting and Data System (BI-RADS)22 assessment of 0 to 5 were eligible (eFigure).

Comparison Group

Screening examinations in non-PHBC women were matched 1:1 to screens of PHBC women, based on Breast Imaging Reporting and Data System22 breast density, 10-year age group, and mammography registry and year. Screening mammograms were defined with BCSC definitions with criteria similar to those of PHBC women (bilateral mammogram indicated for screening in women with no reported symptoms, no mammogram in the previous 9 months, and at least 1 year of follow-up).23

Demographic Characteristics

Age group, self-reported race/ethnicity, family breast cancer history, menopausal status, time since last mammogram, and history of breast plastic surgery (implants, reduction, or reconstruction) were collected at the screening.

Cancer Characteristics and Follow-up

Time since first cancer was the difference between the screening mammogram date and the date of first breast cancer diagnosis. For first cancer, type (ductal carcinoma in situ, stage I or II invasive), radiation therapy, adjuvant systemic therapy, and surgery (breast-conserving surgery, mastectomy) were computed from all cancer registry records and pathology databases that were within 6 months of initial diagnosis. For missing surgery information, self-reported mastectomy and lumpectomy history (collected at a mammogram within 18 months after diagnosis and before a second cancer diagnosis) was used to impute primary surgery.

In all screening participants, mammograms were considered to be associated with an outcome of breast cancer if ductal carcinoma in situ or invasive carcinoma was observed within 1 year of the screen.

Statistical Analysis and Measures of Accuracy

Because some mammography facilities add spot-compression magnification views to routine screening views as a standard part of screening PHBC women, accuracy measures were based on the final assessment at the end of imaging evaluation, using the BI-RADS22 scale. If the initial examination assessment was BI-RADS score 0 without biopsy recommendation or was 1, 2, or 3 with immediate follow-up recommendation, we looked for a final assessment in imaging examinations up to 90 days after screening and before breast biopsy. A positive final assessment result included BI-RADS assessments of 4 or 5, or 0 or 3 with recommendation for biopsy, fine-needle aspiration, or surgical consultation.1,23,24 A negative final assessment result included BI-RADS assessments of 1 or 2; assessment of 3 without recommendation for biopsy, fine-needle aspiration, or surgical consultation; or assessment of 0 with normal or short-interval follow-up recommendation. Final assessment was considered missing if the last BI-RADS assessment was 0 with recommendation for additional imaging, unspecified evaluation, or missing recommendation (eFigure).

Accuracy measures were based on standard BCSC definitions.23 A positive mammogram result associated with breast cancer diagnosis during follow-up (within 1 year of screen) was defined as a true positive (or false positive if not associated with cancer diagnosis). A negative mammogram result not associated with breast cancer during follow-up was a true negative (or false negative if associated with cancer during follow-up). Cancer rate (number of cancers observed during follow-up among 1000 screening mammograms), cancer detection rate (number of true-positive results among 1000 mammograms), interval cancer rate (number of false-negative results among 1000 mammograms), abnormal interpretation rate (proportion of mammograms found to be positive), and positive predictive value of biopsy recommendation (proportion of positive results associated with cancer diagnosis during follow-up)25 were based on standard BCSC definitions.23 Accuracy analyses excluded mastectomy-side recurrences (which would not have been examined with mammography) in PHBC women.

Frequency distributions of screens and cancer characteristics were computed separately for screening mammograms in women with and without PHBC and were compared with χ2 tests. Accuracy and outcome measures and 95% confidence intervals (CIs) were computed within cohorts and compared with score statistics obtained from generalized estimating equation analyses. In PHBC screens, accuracy and cancer rates were examined by breast density, time since first cancer diagnosis, type of first breast cancer, screening interval, and treatment variables associated with first cancer. Post hoc logistic regression tested for differences in sensitivity by systemic therapy for first cancer (none, chemotherapy, endocrine therapy, or both), adjusting for exact age, breast density, stage and treatment of first cancer, and mammography registry. Generalized estimating equations were used to calculate all CIs and to fit regression models accounting for correlation in women with multiple screening mammograms. P < .05 (2-sided) was considered statistically significant. Analyses were performed with SAS version 9.2 (SAS Institute, Cary, North Carolina).

There were 58 870 screening mammograms in 19 078 women with PHBC and 58 870 matched screening examinations in 55 315 women without PHBC (Table 1). A higher proportion of screening mammograms from PHBC women relative to matched non-PHBC screens was associated with a family history of breast cancer (23.2% vs 17.6%), postmenopausal status (91.6% vs 87.5%), history of breast plastic surgery (6.9% vs 0.8%), and receipt of mammography between 9 and 14 months since the previous screen (82.7% vs 43.1%); all P < .001. Women with PHBC had 655 second cancers (499 invasive, 156 ductal carcinoma in situ) and women without PHBC had 342 cancers (285 invasive, 57 ductal carcinoma in situ) within 1 year of screening mammography. Ductal carcinoma in situ occurred in a higher proportion of second cancers in the PHBC than in the non-PHBC group (23.8% vs 16.7%; P = .009).

Table Graphic Jump LocationTable 1. Characteristics of Screening Mammograms in Women With a Personal History of Breast Cancer (PHBC) and Matched Screening Mammograms in Women Without a PHBC

Table 2 reports accuracy measures and outcomes for all screening examinations. Cancer rates were 11.1 per 1000 screens in PHBC women, or 10.5 per 1000, excluding 40 mastectomy-side recurrences that would not have been examined with mammography, relative to 5.8 per 1000 screens in non-PHBC women. Cancer rates, cancer detection rate, and interval cancer rate were 1.3 to 2.6 times higher for PHBC screens compared with matched screens. PHBC screens were more frequently associated with additional imaging (additional mammography views or ultrasonography) than matched screens (18.1% vs 8.3%; P < .001), which was largely due to more same-day additional imaging in PHBC screens relative to matched screens (12.4% vs 1.3%; P < .001) rather than recall for additional imaging (7.1% vs 7.8%; P < .001). PHBC women were more likely to have a recommendation for fine-needle aspiration, biopsy, or surgical consultation after assessment (2.2% vs 1.4%; P < .001). Ultrasonography was performed as part of the evaluation (same day, before, or at final assessment) of positive screening mammogram results (1874 positive screen results) less frequently in PHBC-positive screens than in matched screens (32.3% vs 38.8%; P = .004).

Table Graphic Jump LocationTable 2. Screening Mammography Accuracy and Outcomes in Women With a Personal History of Breast Cancer (PHBC) and Matched Screening Mammograms in non-PHBC Women

Screening sensitivity in PHBC was lower (65.4%; 95% CI, 61.5%-69.0%) compared with that in non-PHBC screens (76.5%; 95% CI, 71.7%-80.7%), P < .001. This relatively lower screening sensitivity was largely due to lower sensitivity for detection of invasive cancer in PHBC (61.1%; 95% CI, 56.6%-65.4%) relative to that in the matched group (75.7%; 95% CI, 70.4%-80.3%), P < .001. In PHBC screens, cancer detection rate was higher in women whose first cancer was ductal carcinoma in situ relative to invasive cancer (Table 2), and this was evident for detection of both ductal carcinoma in situ and invasive second cancers. Sensitivity was similar for detection of ipsilateral (66.3%; 95% CI, 60.3%-71.8%) and contralateral cancer (66.1%; 95% CI, 60.9%-70.9%), P = .96; and sensitivity was higher for detection of ductal carcinoma in situ (78.7%; 95% CI, 71.4%-84.5%) than for invasive cancer (61.1%; 95% CI, 56.6%-65.4%), P < .001.

Accuracy, cancer rates, cancer detection rate, and interval cancer rate in PHBC women are reported by age, breast density, screening interval, time since first cancer diagnosis, type of first cancer, treatment for first breast cancer, and breast plastic surgery history (Table 3) (data used in the calculations are shown in eTable 1). Table 4 shows screening sensitivity for these variables by second cancer laterality. Accuracy measures, cancer rates, and interval cancer rate were associated with age, although the lower sensitivity in women younger than 50 years was more evident for contralateral cancer detection. Sensitivity and specificity decreased and abnormal interpretation rate, cancer rates, cancer detection rate, and interval cancer rate increased with increasing BI-RADS22 density categories. Sensitivity was 69.6% (95% CI, 63.3%-75.3%) in less dense breasts (BI-RADS category 1-2) and was higher than the sensitivity of 60.2% (95% CI, 54.0%-66.2%) in more dense breasts (BI-RADS category 3-4), P = .03.

Table Graphic Jump LocationTable 3. Screening Mammography Accuracy and Cancer Rates in Women With a Personal History of Breast Cancer (n = 58830 Screens)
Table Graphic Jump LocationTable 4. Detection of Ipsilateral and Contralateral Breast Cancers in Women With a Personal History of Breast Cancer

Specificity and positive predictive value increased, sensitivity and cancer detection rate varied, and abnormal interpretation rate decreased with increasing time since first cancer diagnosis (Table 3). Sensitivity in the initial 5 years from first cancer (60.2%; 95% CI, 54.7%-65.5%) was lower than sensitivity after 5 years (70.8%; 95% CI, 65.4%-75.6%), P = .006. Cancer detection rate also differed between the initial 5 years (5.8/1000 screens; 95% CI, 5.0-6.7) and after the initial 5 years (8.1/1000 screens; 95% CI, 7.1-9.3) from first cancer diagnosis, P < .001, predominantly because of increased cancer detection rate for invasive cancer between the initial 5 years (3.7/1000 screens; 95% CI, 3.1-4.4) and after the initial 5 years (6.2/1000 screens; 95% CI, 5.3-7.2), P < .001.

Specificity and abnormal interpretation rate were associated with time since previous mammogram (Table 3); however, most PHBC screens occurred between 9 and 14 months after previous mammography. Sensitivity, abnormal interpretation rate, positive predictive value, cancer rates, and cancer detection rate were higher in women with previous ductal carcinoma in situ relative to those with previous invasive cancer (Table 3), although the sensitivity difference was more evident for detection of ipsilateral (second) cancers (Table 4).

Specificity was higher and abnormal interpretation rate lower in women who had received mastectomy relative to breast-conserving surgery for first cancer. Radiation therapy was associated with a very small but significant specificity reduction and abnormal interpretation rate increase. Cancer rates, cancer detection rate, and interval cancer rate varied between women who had breast-conserving surgery with or without radiation or mastectomy (Table 3): the highest cancer detection and interval cancer rates were observed in women treated with breast-conserving surgery without radiation for their first cancer. Sensitivity, abnormal interpretation rate, and positive predictive value were higher in women who had not received any systemic therapies, as were underlying cancer rates and cancer detection rate (Table 3). After adjusting for age, density, stage and treatment of first cancer, and mammography registry, women with chemotherapy were significantly less likely to have their cancer detected by mammography (odds ratio [OR] = 0.45; 95% CI, 0.22-0.94) than women without systemic therapy. Women with endocrine therapy alone (OR = 0.63; 95% CI, 0.35-1.15) or combined with chemotherapy (OR = 0.69; 95% CI, 0.29-1.67) also had lower sensitivity than women with no therapy, but this was nonsignificant.

Sensitivity and positive predictive value were lower in screens with self-reported breast plastic surgery history relative to no plastic surgery (lower sensitivity was more apparent when reduction was excluded), but overall this was not significant (Table 3). The lower sensitivity in screens with self-reported breast plastic surgery was evident mainly for contralateral cancer (Table 4); however, the number in this group was small.

Stage and node status for cancers occurring within 1 year of screening are in eTable 2, with generally similar stage distributions for interval cancers in both cohorts, although invasive interval cancers were more likely to be stage I than stage II in PHBC women compared with non-PHBC women. Screen-detected cancers had a favorable profile in PHBC women and matched screens, with the majority being early-stage cancers.

Breast cancer survivors represent an increasing group and are at risk of cancer in the conserved and contralateral breast. To our knowledge, we report the first comprehensive study of accuracy measures of mammography screening in PHBC women that includes both ipsilateral and contralateral breast screening outcomes, providing evidence to inform practice and guide recommendations on mammography screening in PHBC women.7,9,10 Key findings are that mammography screening in PHBC women detects cancers at an early stage but has lower accuracy than screening in women without PHBC, despite a higher rate of additional evaluation and higher underlying cancer rates in PHBC women. Our study also shows that screening mammography in PHBC women has a relatively high interval cancer rate, although most interval cancers in these women had favorable tumor stage profiles.

Because population mammography screening accuracy differs across screening programs and countries, a major strength of our study is integration of matched screens from women without PHBC, providing context on screening accuracy in mammography registries that contributed data to this study and allowing judgment about the generalizability of our findings. It also allows an understanding of mammography screening outcomes and how these differ in PHBC women relative to non-PHBC women, as highlighted in Table 2. Measures of screening accuracy should, however, be interpreted with awareness that these calculations were based on final assessment (at completion of imaging evaluation). Our design of matching screening mammograms for characteristics including breast density and age group allowed us to validly compare screening accuracy between the 2 groups. Although different numbers of women were required to achieve the necessary mammogram-level matching, our estimates for cancer rates, cancer detection rate, and interval cancer rate are reported per 1000 screening examinations, with follow-up set at 12 months for all screens, allowing unbiased comparison of these rates between the 2 groups. Furthermore, the majority of women in both groups reported having mammography before that included in our analysis (Table 1); hence, our estimates represent predominantly incident (repeated) screening outcomes and allow analytically for clustering in women with multiple screens.

In general, screening did not perform as well in PHBC women relative to that in women without PHBC: sensitivity and specificity were lower for PHBC women, and screening examinations were approximately twice as likely to be recommended for additional imaging or biopsy. Screening positive predictive value was similar in both groups, in part because of the higher cancer incidence in PHBC women. Cancer rates, cancer detection rate, interval cancer rate, and the proportion of cancers that were interval cancers were significantly higher in PHBC women, highlighting their higher underlying risk of breast cancer, as well as their relatively lower screening sensitivity. Despite the lower sensitivity, the stage distribution of screen-detected cancers shows that mammography is effective in detecting early-stage second breast cancers in PHBC women because the majority were ductal carcinoma in situ or stage I cancers. Our findings support annual mammography screening recommendations in PHBC women7,8,10 but also highlight issues needing further evaluation.

We report a relatively high interval cancer rate in PHBC women, even though the majority of screens were conducted between 9 and 14 months after the previous mammogram. We cannot compare our interval cancer rate to that of other studies because, to our knowledge, this is the first report of interval cancer rate for screening PHBC women that factors ascertainment of both ipsilateral and contralateral breast outcomes and a relative interval cancer rate for matched screens in women without PHBC. One other study of population-based screening of women with PHBC,26 based on 114 women with contralateral cancer, reported sensitivities of 59.6% overall and 70.8% for the subgroup with annual mammography. Screening specificity was 98.3% and the proportion of contralateral breast cancers that were interval cancers was 34.2%26 (similar to data in Table 2); however, interval cancer rate was not reported. Buist et al1 recently reported that about one-third of second breast cancers in BCSC women were not screen detected. Comparison of our work with other studies of PHBC women is not appropriate because the latter generally reports the proportion of second cancers detected by mammography in selected series of PHBC women and does not provide valid data on all measures of screening accuracy.6,13

We used final assessment to calculate screening accuracy rather than initial interpretation based only on the screening mammogram because a substantial number of PHBC women had additional imaging on the same day as the screen. We were unable to distinguish the extent to which this represented evaluation of screen-detected abnormalities or additional imaging performed as standard of care for PHBC women at some facilities. An absolute estimate of screening “recall rate” that includes callback for additional imaging could therefore not be estimated. Our “abnormal” assessment measure was based on a recommendation for biopsy or surgical consultation, whereas studies of population breast screening accuracy often consider recommendations for additional imaging as a positive result. Thus, our abnormal interpretation rate, sensitivity, and specificity are not directly comparable to the recall rate, sensitivity, and specificity usually reported in population screening evaluations, and studies focusing on PHBC women have not reported screening recall rates.6,13 Our study provides valid relative estimates of accuracy measures, including a significantly higher abnormal interpretation rate and lower sensitivity and specificity in PHBC women relative to non-PHBC women. We also found that additional imaging at initial screening was more than twice as frequent among PHBC women, although this was predominantly due to same-day additional imaging in PHBC women.

Screening examinations of PHBC women revealed an approximately 2-fold higher risk of breast cancer during follow-up relative to screens of women without PHBC, matched for age, breast density, mammography registry, and year. Underlying cancer rates were lower in PHBC women who had mastectomy rather than breast-conserving surgery for the first cancer and were similar to cancer rates in the matched non-PHBC cohort (Tables 2 and 3), which is consistent with recent risk models that estimated that lifetime risk of breast cancer in PHBC women is a function of the number of breasts at risk for developing another cancer.20 This may also partly account for the higher specificity and lower cancer rates found in PHBC women with mastectomy in our data. Our study shows that PHBC women have heterogeneous risk for developing another breast cancer; thus, consideration of a more tailored screening approach might be warranted in some PHBC women, according to our estimates for underlying cancer rates and screening sensitivity. The highest observed cancer rates in our PHBC cohort (>12 cancers/1000 screens, or greater than twice the cancer rates in non-PHBC women) were in women younger than 50 years, women with extremely dense breasts, women with previous ductal carcinoma in situ, women who received breast-conserving surgery without radiation or did not receive any systemic therapy, and those with interscreening interval greater than 2 years.

We were surprised to find higher mammography sensitivity (evident for ipsilateral and contralateral cancer) in women who had not received systemic therapy, for whom underlying cancer rates were also higher compared with those who received chemotherapy or endocrine therapy. Examination of this association, after adjusting for relevant variables, showed significantly reduced sensitivity only in women who received chemotherapy. Because receipt of systemic therapy was based on cancer registry information, the data might have been incomplete. Further research examining whether this finding may be due to potential confounding by biological factors associated with first cancer treatment (for example, hormone receptor status) would be valuable. Similarly, some of our findings should be interpreted with consideration of possible confounding by factors associated with the first cancer and its treatment. For example, the higher cancer rates, cancer detection rate, and screening sensitivity in PHBC women whose first cancer was ductal carcinoma in situ may be reflecting the effect of use of systemic therapy (usually not used for ductal carcinoma in situ and frequently used for invasive cancer), which reduces the risk of another breast cancer, rather than a differential biological susceptibility in women with personal history of ductal carcinoma in situ relative to invasive cancer.

The interval cancer rate we report for PHBC women might raise concerns about whether the potential benefit of screening is fully realized in these women. Although there is interest in adjunct screening for PHBC women,19,20,27 there is no evidence that this improves clinical end points and no consensus regarding which of these women (other than those with proven cancer gene mutations) should have adjunct imaging. Furthermore, despite a relatively high interval cancer rate in PHBC women, interval cancers were predominantly early stage, although the proportion of stage IIB and III cancers was slightly higher than that of non-PHBC interval cancers. Thus, although mammography screening is less sensitive in PHBC women, our study provides evidence that both screen-detected and interval cancers are, in general, equally early stage among PHBC women and those without PHBC. These data neither support nor negate a role for adjunct screening in PHBC women but suggest that adjunct screening should be studied in women younger than 50 years, women with denser breasts, or those who received chemotherapy for their first cancer because screening these women had the lowest sensitivity among PHBC women. The data also raise consideration of exploring alternate approaches, such as biomarkers, for future screening in PHBC women. Evaluation of adjunct (or alternate) screening might be considered in PHBC subgroups in whom unacceptably high interval cancer rates were found (for example, interval cancer rate ≥6 cancers/1000 screens), including women younger than 50 years, women with extremely dense breasts, and those who received breast conservation without radiotherapy for their first cancer.

Our findings on interval cancers in PHBC women raise several possibilities. First, PHBC women may have different host factors predisposing them not only to risk of a second breast cancer but also to breast cancers that are less likely to be detected with screening, possibly because of more rapid growth or other tumor biology characteristics. Second, they may partly reflect higher breast awareness by PHBC women, who might seek help promptly for breast symptoms. Third, assuming that many interval cancers in PHBC women are symptomatic diagnoses is reasonable, but some interval cancers may be due to adjunct screening (magnetic resonance imaging or ultrasonography) occurring in between mammography screenings. We did not have data to examine adjunct screening as a possible explanation for the early-stage interval cancers in PHBC women, but guidelines for magnetic resonance imaging screening in high-risk women were available at the end of our study.19

This study provides evidence that screening mammography detects early-stage breast cancers in PHBC women but has lower accuracy relative to screening women without PHBC. Despite a relatively high interval cancer rate, interval cancers in PHBC women had generally favorable stage distributions. Our work also shows that screening outcomes and breast cancer rates in PHBC women are associated with various factors, including the treatment received for the first cancer, so these women have heterogeneous underlying risks for a second breast cancer, and a more tailored screening strategy than currently recommended might be warranted.

Corresponding Author: Nehmat Houssami, MBBS, PhD, Screening and Test Evaluation Program, School of Public Health (A27), Sydney Medical School, University of Sydney, NSW 2006, Australia (nehmath@med.usyd.edu.au).

Author Contributions: Dr Miglioretti had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Houssami, Miglioretti, Buist, Irwig.

Acquisition of data: Miglioretti, Kerlikowske, Buist, Geller.

Analysis and interpretation of data: Houssami, Abraham, Miglioretti, Sickles, Kerlikowske, Buist, Geller, Muss.

Drafting of the manuscript: Houssami, Abraham, Miglioretti.

Critical revision of the manuscript for important intellectual content: Houssami, Miglioretti, Sickles, Kerlikowske, Buist, Geller, Muss, Irwig.

Statistical analysis: Houssami, Abraham, Miglioretti.

Obtained funding: Miglioretti, Kerlikowske, Buist, Irwig.

Administrative, technical, or material support: Houssami, Kerlikowske, Buist.

Study supervision: Houssami, Miglioretti, Kerlikowske, Irwig.

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Funding/Support: This work was supported by the National Cancer Institute (NCI)–funded BCSC cooperative agreement (U01CA63740, U01CA86076, U01CA86082, U01CA63736, U01CA70013, U01CA69976, U01CA63731, and U01CA70040). The collection of cancer data used in this study was supported in part by several state public health departments and cancer registries throughout the United States. For a full description of these sources, see http://www.breastscreening.cancer.gov/work/acknowledgement.html. This work was also partly funded by Australia's National Health and Medical Research Council program grant 402764 to the Screening and Test Evaluation Program.

Role of the Sponsor: The sponsors did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The BCSC Steering Committee reviewed the manuscript.

Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCI or the National Institutes of Health.

Additional Contributions: This study is dedicated to the many women who have been personally affected by breast cancer. We thank the participating women, mammography facilities, and radiologists for the data they provided for this study. A list of the BCSC investigators and procedures for requesting BCSC data for research purposes are provided at http://breastscreening.cancer.gov. We thank Chris Tachibana, PhD (Group Health Research Institute, Seattle), for assistance with scientific editing of this article. She did not receive financial compensation for her contributions.

Buist DS, Abraham LA, Barlow WE,  et al; Breast Cancer Surveillance Consortium.  Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer.  Breast Cancer Res Treat. 2010;124(3):863-873
PubMed   |  Link to Article
Lu WL, Jansen L, Post WJ,  et al.  Impact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysis.  Breast Cancer Res Treat. 2009;114(3):403-412
PubMed   |  Link to Article
Houssami N, Ciatto S, Martinelli F,  et al.  Early detection of second breast cancers improves prognosis in breast cancer survivors.  Ann Oncol. 2009;20(9):1505-1510
PubMed   |  Link to Article
Lash TL, Fox MP, Buist DS,  et al.  Mammography surveillance and mortality in older breast cancer survivors.  J Clin Oncol. 2007;25(21):3001-3006
PubMed   |  Link to Article
Ciatto S, Miccinesi G, Zappa M. Prognostic impact of the early detection of metachronous contralateral breast cancer.  Eur J Cancer. 2004;40(10):1496-1501
PubMed   |  Link to Article
Houssami N, Ciatto S. Mammographic surveillance in women with a personal history of breast cancer: how accurate? how effective?  Breast. 2010;19(6):439-445
PubMed  |  Link to Article   |  Link to Article
Khatcheressian JL, Wolff AC, Smith TJ,  et al.  American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting.  J Clin Oncol. 2006;24(31):5091-5097
PubMed   |  Link to Article
Lee CH, Dershaw DD, Kopans D,  et al.  Breast cancer screening with imaging: recommendations from the Society of Breast Imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer.  J Am Coll Radiol. 2010;7(1):18-27
PubMed   |  Link to Article
Hayes DF. Clinical practice: follow-up of patients with early breast cancer.  N Engl J Med. 2007;356(24):2505-2513
PubMed   |  Link to Article
Carlson RW, Allred DC, Anderson BO,  et al; NCCN Breast Cancer Clinical Practice Guidelines Panel.  Breast cancer: clinical practice guidelines in oncology.  J Natl Compr Canc Netw. 2009;7(2):122-192
PubMed
Association of Breast Surgery at the BASO Royal College of Surgeons of England.  Guidelines for the management of symptomatic breast disease.  Eur J Surg Oncol. 2005;31:S1-S21
Schwartz GF, Veronesi U, Clough KB,  et al; Consensus Conference Committee.  Consensus conference on breast conservation.  J Am Coll Surg. 2006;203(2):198-207
PubMed   |  Link to Article
Grunfeld E, Noorani H, McGahan L,  et al.  Surveillance mammography after treatment of primary breast cancer.  Breast. 2002;11(3):228-235
PubMed   |  Link to Article
Montgomery DA, Krupa K, Cooke TG. Follow-up in breast cancer: does routine clinical examination improve outcome?  Br J Cancer. 2007;97(12):1632-1641
PubMed   |  Link to Article
Dershaw DD, McCormick B, Osborne MP. Detection of local recurrence after conservative therapy for breast carcinoma.  Cancer. 1992;70(2):493-496
PubMed   |  Link to Article
Temple LK, Wang EE, McLeod RS.Canadian Task Force on Preventive Health Care.  Preventive health care, 1999 update, 3: follow-up after breast cancer.  CMAJ. 1999;161(8):1001-1008
PubMed
Stomper PC, Recht A, Berenberg AL,  et al.  Mammographic detection of recurrent cancer in the irradiated breast.  AJR Am J Roentgenol. 1987;148(1):39-43
PubMed   |  Link to Article
Fowble B, Solin LJ, Schultz DJ,  et al.  Breast recurrence following conservative surgery and radiation: patterns of failure, prognosis, and pathologic findings from mastectomy specimens with implications for treatment.  Int J Radiat Oncol Biol Phys. 1990;19(4):833-842
PubMed   |  Link to Article
Saslow D, Boetes C, Burke W,  et al.  American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.  CA Cancer J Clin. 2007;57(2):75-89
PubMed   |  Link to Article
Punglia RS, Hassett MJ. Using lifetime risk estimates to recommend magnetic resonance imaging screening for breast cancer survivors.  J Clin Oncol. 2010;28(27):4108-4110
PubMed   |  Link to Article
American Joint Committee on Cancer.  AJCC Cancer Staging Manual. 5th ed. Philadelphia, PA: Lippincott-Raven; 1997
 Breast Imaging Reporting and Data System (BI-RADS). Reston, VA: American College of Radiology; 1998
 Breast Cancer Surveillance Consortium (BCSC): performance benchmarks for screening mammography. http://breastscreening.cancer.gov/data/benchmarks/screening/. Accessed August 8, 2010
Rosenberg RD, Yankaskas BC, Abraham LA,  et al.  Performance benchmarks for screening mammography.  Radiology. 2006;241(1):55-66
PubMed   |  Link to Article
Sickles EA, Miglioretti DL, Ballard-Barbash R,  et al.  Performance benchmarks for diagnostic mammography.  Radiology. 2005;235(3):775-790
PubMed   |  Link to Article
Lu W, Schaapveld M, Jansen L,  et al.  The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer.  Eur J Cancer. 2009;45(17):3000-3007
PubMed   |  Link to Article
Berg WA, Blume JD, Cormack JB,  et al; ACRIN 6666 Investigators.  Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.  JAMA. 2008;299(18):2151-2163
PubMed   |  Link to Article

Figures

Tables

Table Graphic Jump LocationTable 1. Characteristics of Screening Mammograms in Women With a Personal History of Breast Cancer (PHBC) and Matched Screening Mammograms in Women Without a PHBC
Table Graphic Jump LocationTable 4. Detection of Ipsilateral and Contralateral Breast Cancers in Women With a Personal History of Breast Cancer
Table Graphic Jump LocationTable 3. Screening Mammography Accuracy and Cancer Rates in Women With a Personal History of Breast Cancer (n = 58830 Screens)
Table Graphic Jump LocationTable 2. Screening Mammography Accuracy and Outcomes in Women With a Personal History of Breast Cancer (PHBC) and Matched Screening Mammograms in non-PHBC Women

References

Buist DS, Abraham LA, Barlow WE,  et al; Breast Cancer Surveillance Consortium.  Diagnosis of second breast cancer events after initial diagnosis of early stage breast cancer.  Breast Cancer Res Treat. 2010;124(3):863-873
PubMed   |  Link to Article
Lu WL, Jansen L, Post WJ,  et al.  Impact on survival of early detection of isolated breast recurrences after the primary treatment for breast cancer: a meta-analysis.  Breast Cancer Res Treat. 2009;114(3):403-412
PubMed   |  Link to Article
Houssami N, Ciatto S, Martinelli F,  et al.  Early detection of second breast cancers improves prognosis in breast cancer survivors.  Ann Oncol. 2009;20(9):1505-1510
PubMed   |  Link to Article
Lash TL, Fox MP, Buist DS,  et al.  Mammography surveillance and mortality in older breast cancer survivors.  J Clin Oncol. 2007;25(21):3001-3006
PubMed   |  Link to Article
Ciatto S, Miccinesi G, Zappa M. Prognostic impact of the early detection of metachronous contralateral breast cancer.  Eur J Cancer. 2004;40(10):1496-1501
PubMed   |  Link to Article
Houssami N, Ciatto S. Mammographic surveillance in women with a personal history of breast cancer: how accurate? how effective?  Breast. 2010;19(6):439-445
PubMed  |  Link to Article   |  Link to Article
Khatcheressian JL, Wolff AC, Smith TJ,  et al.  American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting.  J Clin Oncol. 2006;24(31):5091-5097
PubMed   |  Link to Article
Lee CH, Dershaw DD, Kopans D,  et al.  Breast cancer screening with imaging: recommendations from the Society of Breast Imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer.  J Am Coll Radiol. 2010;7(1):18-27
PubMed   |  Link to Article
Hayes DF. Clinical practice: follow-up of patients with early breast cancer.  N Engl J Med. 2007;356(24):2505-2513
PubMed   |  Link to Article
Carlson RW, Allred DC, Anderson BO,  et al; NCCN Breast Cancer Clinical Practice Guidelines Panel.  Breast cancer: clinical practice guidelines in oncology.  J Natl Compr Canc Netw. 2009;7(2):122-192
PubMed
Association of Breast Surgery at the BASO Royal College of Surgeons of England.  Guidelines for the management of symptomatic breast disease.  Eur J Surg Oncol. 2005;31:S1-S21
Schwartz GF, Veronesi U, Clough KB,  et al; Consensus Conference Committee.  Consensus conference on breast conservation.  J Am Coll Surg. 2006;203(2):198-207
PubMed   |  Link to Article
Grunfeld E, Noorani H, McGahan L,  et al.  Surveillance mammography after treatment of primary breast cancer.  Breast. 2002;11(3):228-235
PubMed   |  Link to Article
Montgomery DA, Krupa K, Cooke TG. Follow-up in breast cancer: does routine clinical examination improve outcome?  Br J Cancer. 2007;97(12):1632-1641
PubMed   |  Link to Article
Dershaw DD, McCormick B, Osborne MP. Detection of local recurrence after conservative therapy for breast carcinoma.  Cancer. 1992;70(2):493-496
PubMed   |  Link to Article
Temple LK, Wang EE, McLeod RS.Canadian Task Force on Preventive Health Care.  Preventive health care, 1999 update, 3: follow-up after breast cancer.  CMAJ. 1999;161(8):1001-1008
PubMed
Stomper PC, Recht A, Berenberg AL,  et al.  Mammographic detection of recurrent cancer in the irradiated breast.  AJR Am J Roentgenol. 1987;148(1):39-43
PubMed   |  Link to Article
Fowble B, Solin LJ, Schultz DJ,  et al.  Breast recurrence following conservative surgery and radiation: patterns of failure, prognosis, and pathologic findings from mastectomy specimens with implications for treatment.  Int J Radiat Oncol Biol Phys. 1990;19(4):833-842
PubMed   |  Link to Article
Saslow D, Boetes C, Burke W,  et al.  American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.  CA Cancer J Clin. 2007;57(2):75-89
PubMed   |  Link to Article
Punglia RS, Hassett MJ. Using lifetime risk estimates to recommend magnetic resonance imaging screening for breast cancer survivors.  J Clin Oncol. 2010;28(27):4108-4110
PubMed   |  Link to Article
American Joint Committee on Cancer.  AJCC Cancer Staging Manual. 5th ed. Philadelphia, PA: Lippincott-Raven; 1997
 Breast Imaging Reporting and Data System (BI-RADS). Reston, VA: American College of Radiology; 1998
 Breast Cancer Surveillance Consortium (BCSC): performance benchmarks for screening mammography. http://breastscreening.cancer.gov/data/benchmarks/screening/. Accessed August 8, 2010
Rosenberg RD, Yankaskas BC, Abraham LA,  et al.  Performance benchmarks for screening mammography.  Radiology. 2006;241(1):55-66
PubMed   |  Link to Article
Sickles EA, Miglioretti DL, Ballard-Barbash R,  et al.  Performance benchmarks for diagnostic mammography.  Radiology. 2005;235(3):775-790
PubMed   |  Link to Article
Lu W, Schaapveld M, Jansen L,  et al.  The value of surveillance mammography of the contralateral breast in patients with a history of breast cancer.  Eur J Cancer. 2009;45(17):3000-3007
PubMed   |  Link to Article
Berg WA, Blume JD, Cormack JB,  et al; ACRIN 6666 Investigators.  Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.  JAMA. 2008;299(18):2151-2163
PubMed   |  Link to Article
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