A review of the recurrence risk literature uncovers several paradoxical observations: thrombophilias predispose for a first episode of deep venous thrombosis (DVT) but not for recurrence (the thrombophilia paradox1); aspirin users are at lower risk for cardiac events, but higher risk of recurrence (the aspirin paradox2); and although obesity is an established risk factor for coronary artery disease, it appears to protect against recurrent coronary events (the obesity paradox3). Although several hypotheses have been proposed to explain these paradoxes, it is not generally appreciated that all recurrent risk analyses are prone to a particular bias that may induce such paradoxical results. This phenomenon could be referred to as index event bias because it arises in studies that select patients based on the occurrence of an index event.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 55
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.