For nearly 3 decades, basic science researchers have used electric pulses to make cell membranes transiently permeable to deliver DNA and other molecules into cells. Now, clinical investigators are applying this method to introduce chemotherapeutics to cancer cells by inserting electrodes into a tumor. Such electrochemotherapy has proven to be an effective local treatment for various types of tumors, particularly when electric pulses are applied with chemotherapeutics that pass through the cell membrane with difficulty or not at all.
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Electrochemotherapy involving intravenous bleomycin followed by electric pulses, given as palliative treatment for a patient with malignant melanoma, eliminated tumor nodules on the patient's scalp (Ugeskr Laeger. 2005;167:3156-3159).
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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