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Maternal Depression and Child Development After Prenatal DHA Supplementation

Takefumi Suzuki, MD, PhD
JAMA. 2011;305(4):359-361. doi:10.1001/jama.2011.17.
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To the Editor: In their randomized controlled trial, Dr Makrides and colleagues1 found that prenatal supplementation with docosahexaenoic acid (DHA) compared with placebo did not lower levels of postpartum depression (adjusted relative risk [RR], 0.85; 95% confidence interval [CI], 0.70-1.02; P = .09). Depression was defined as a score of greater than 12 on the Edinburgh Postnatal Depression Scale (EPDS), which has a possible score range of 0 to 30 with higher scores indicating more severity. However, it is important to examine between-group differences in the actual score in the EPDS as a continuous rather than dichotomous variable.

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January 26, 2011
Johanna Assies, MD, PhD; Roel J. T. Mocking, BSc; François Pouwer, PhD
JAMA. 2011;305(4):359-361. doi:10.1001/jama.2011.18.
January 26, 2011
Maria Makrides, BSc, BND, PhD; Lisa Yelland, BSc; Robert Gibson, BSc, PhD
JAMA. 2011;305(4):359-361. doi:10.1001/jama.2011.19.
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