Author Contributions: Dr Yaffe had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Yaffe, Ding.
Acquisition of data: Yaffe, Satterfield, Simonsick, S. G. Younkin, L. H. Younkin, Ding, Harris.
Analysis and interpretation of data: Yaffe, Weston, Graff-Radford, Simonsick, L. H. Younkin, Kuller, Ayonayon, Ding.
Drafting of the manuscript: Yaffe, Weston, Ding.
Critical revision of the manuscript for important intellectual content: Weston, Graff-Radford, Satterfield, Simonsick, S. G. Younkin, L. H. Younkin, Kuller, Ayonayon, Ding, Harris.
Statistical analysis: Weston.
Obtained funding: Yaffe.
Administrative, technical, or material support: Yaffe, Satterfield, Simonsick, L. H. Younkin, Ayonayon, Ding, Harris.
Study supervision: S. G. Younkin, L. H. Younkin.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was funded by National Institute on Aging contracts N01-AG62101, N01-AG62103, and N01-AG62106. This research was supported in part by the Intramural Research Program of the National Institute on Aging. Dr Yaffe is supported in part by National Institute on Aging grant K24AG031155 and by an anonymous foundation.
Role of the Sponsor: The Intramural Research Program of the National Institute on Aging participated in the design and conduct of the study; in the collection, analysis, and interpretation of the data; and in the preparation, review, and approval of the manuscript.