Author Contributions: Dr Foulkes had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Rio Frio, Livingston, Foulkes, Tischkowitz.
Acquisition of data: Rio Frio, Bahubeshi, Kanellopoulou, Hamel, Niedziela, Sabbaghian, Pouchet, Gilbert, O’Brien, Serfas, Houlston, Lesueur, Bonora, Muljo, Schimke, Arseneau, Nguyen, Harach, Foulkes, Tischkowitz.
Analysis and interpretation of data: Rio Frio, Bahubeshi, Kanellopoulou, Hamel, Niedziela, Sabbaghian, O’Brien, Broderick, Bouron-Dal Soglio, Arseneau, Schultz, Priest, Nguyen, Harach, Livingston, Foulkes, Tischkowitz.
Drafting of the manuscript: Rio Frio, Bahubeshi, Priest, Foulkes, Tischkowitz.
Critical revision of the manuscript for important intellectual content: Rio Frio, Bahubeshi, Kanellopoulou, Hamel, Niedziela, Sabbaghian, Pouchet, O’Brien, Serfas, Broderick, Houlston, Lesueur, Muljo, Schimke, Bouron-Dal Soglio, Arseneau, Schultz, Nguyen, Livingston, Foulkes, Tischkowitz.
Statistical analysis: Rio Frio.
Obtained funding: Foulkes, Tischkowitz.
Administrative, technical, or material support: Rio Frio, Bahubeshi, Hamel, Niedziela, Sabbaghian, Pouchet, O’Brien, Serfas, Broderick, Houlston, Lesueur, Bonora, Muljo, Schimke, Bouron-Dal Soglio, Arseneau, Schultz, Priest, Nguyen, Harach, Foulkes, Tischkowitz.
Study supervision: Livingston, Foulkes, Tischkowitz.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Priest reported being named in a US patent US2009/068691 regarding certain technical procedures associated with DICER1 testing. Dr Priest has no financial interest and all rights of Dr Priest have been signed over to the Children's Hospitals and Clinics of Minnesota. No other authors reported disclosures.
Funding/Support: The work was funded by the Jewish General Hospital Weekend to End Women's Cancers, the Turner Family Cancer Research Fund, and les Fonds de la Recherche en Santé du Québec (FRSQ). Mr Bahubeshi is funded by the Canadian Institutes of Health Research/FRSQ training grant in cancer research (FRN53888) of the McGill Integrated Cancer Research Training Program. Dr Rio Frio was funded by the Research Institute of the McGill University Health Centre and by the Henry R. Shibata Fellowship of the Cedars Cancer Institute. Dr Priest receives funding support from the Pine Tree Apple Tennis Classic and the Theodora H. Lang Charitable trust. Dr Foulkes holds an FRSQ national scientist award and Dr Tischkowitz holds an FRSQ clinician-scientist award.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: The contents of this article are the sole responsibility of the authors.
Additional Contributions: We would like to thank the patients and families who participated in this study; Debra Collins, MSc, Division of Endocrinology, Metabolism and Genetics, University of Kansas Medical Center, who assisted in contacting one of the families; Archana Srivastava, MSc, Segal Cancer Center, Jewish General Hospital, for her technical support; and Paul Lee, Department of Pathology, McGill University, for his help with accrual of pathology material. Gretchen M. Williams, BS, CCRP, International Pleuropulmonary Registry, Children's Hospitals and Clinics of Minnesota, assisted with data collection and analysis. We thank Robert H. Young, MD, Department of Pathology, Massachusetts General Hospital, for providing information on his previously published series of sporadic SLCT cases; Anne Haegert, BSc, Laboratory for Advanced Genome Analysis, Vancouver Prostate Centre, Vancouver, Canada, for her help with the miRNA expression analysis; and Rami Zahr, BS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Graham Bignell, PhD, Wellcome Trust Sanger Institute, for technical support. None of the individuals named here received compensation for the contributions besides salary.
This article was corrected for errors on January 19, 2011.