Author Contributions: Drs Calin and Croce had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Fabbri and Bottoni contributed equally to this article.
Study concept and design: Fabbri, Bottoni, Calin, Croce.
Acquisition of data: Fabbri, Bottoni, Shimizu, Spizzo, Nicoloso, Rossi, Barbarotto, Cimmino, Adair, Wojcik, Valeri, Calore, Sampath, Fanini, Vannini, Musuraca, Alder, Davuluri, Negrini, Nakamura, Amadori, Kay, Rai, Keating, Kipps, Croce.
Analysis and interpretation of data: Fabbri, Bottoni, Rossi, Dell’Aquila, Rassenti, Calin, Croce.
Drafting of the manuscript: Fabbri, Bottoni, Spizzo, Amadori, Kay, Rai, Keating, Kipps, Calin, Croce.
Critical revision of the manuscript for important intellectual content: Fabbri, Bottoni, Shimizu, Nicoloso, Rossi, Barbarotto, Cimmino, Adair, Wojcik, Valeri, Calore, Sampath, Fanini, Vannini, Musuraca, Dell’Aquila, Alder, Davuluri, Rassenti, Negrini, Nakamura, Kay, Rai, Keating, Kipps, Calin, Croce.
Statistical analysis: Fabbri, Bottoni, Rossi.
Obtained funding: Fabbri, Calin, Croce.
Administrative, technical, or material support: Shimizu, Spizzo, Barbarotto, Cimmino, Adair, Wojcik, Valeri, Calore, Fanini, Vannini, Musuraca, Alder, Nakamura, Amadori.
Study supervision: Calin, Croce.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: Dr Fabbri is supported by a 2009 Kimmel Scholar Award. Dr Cimmino is supported by a fellowship from FIRC (Federazione Italiana Ricerca sul Cancro). Dr Calin is supported by a fellowship from the University of Texas M. D. Anderson Research Trust, a fellowship from The University of Texas System Regents Research Scholar Program, and a grant from the CLL Global Research Foundation. Dr Calin's laboratory is supported in part by the National Institutes of Health, the US Department of Defense, and a Leukemia SPORE Developmental Research Award. Drs Kay and Croce are supported by National Institutes of Health grant R01 CA111953.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data, or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Kay Huebner, PhD (Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus), for critical discussion and reading of the manuscript and Lionel Santibañez, PhD (Department of Scientific Publications, University of Texas M. D. Anderson Cancer Center), for English editing of the manuscript. The persons acknowledged received no financial compensation for their contributions.