JAMA. 1900;XXXIV(3):179. doi:10.1001/jama.1900.02460030053020.
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While one would naturally expect individual variations in the acuity of the olfactory sense, it appears that noteworthy alterations in this function, other than as a result of local disease of the nares, are uncommon, but this may be because close attention has not generally been directed to clinical investigations of the subject. It is conceivable that the peripheral filaments of the olfactory nerve may become the seat of an inflammatory process of varied origin with impairment of the sense of smell; and the same result might be brought about by lesions in the course of the olfactory tract, from the bulb to the as yet unlocated cortical center, such as inflammation, hemorrhage, softening, new-growths, hydrocephalus, laceration, concussion, aneurysm. The situation of the tract at the base of the brain would seem to make it peculiarly susceptible to the operation of such lesions. Infectious processes and toxic influences might also


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