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December 9, 1899, Vol XXXIII, No. 24 >
ARTICLE | December 9, 1899

CONGENITAL VACCIN IMMUNITY.

JAMA. 1899;XXXIII(24):1499-1500. doi:10.1001/jama.1899.02450760055014.
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A comparatively recent joint investigation by MM. Beclere, Chambon, Ménard and Coulomb, reported in the Comptes Rendus of the Paris Academy of Sciences,1 and editorially noticed in an English publication2, is of decided interest as bearing on the living questions of immunity and susceptibility. If we are not mistaken, we have rather recently noticed some clinical observations supporting the results here given. These investigators made observations on sixty-five mothers and an equal number of newly-born infants, and their findings are summed up in the following: immunity to vaccin inoculation was observed only in children whose mothers were immune, and only in a small number of these. The intrauterine transmission occurred in cases where the maternal serum was antivirulent, irrespective of the time when the mother was vaccinated. It was not observed, on the other hand, when the maternal serum was non-antivirulent, although vaccination had been effected shortly before

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