I am greatly indebted to Prof. J. B. Murphy and Dr. W. E. Coates for allowing me to use the clinical history of, and the material from, the following case of blastomycetic infection of the skin of the leg.
—Mrs W., aged 64, married, with an uneventful family and personal history, was admitted into Professor Murphy's clinic, Nov, 10, 1897, on account of a lesion on the right leg, of which she gave the following account: Four months previously a small pimple appeared of itself, on the posterior surface of the lower third of the right leg; three or four days later a second pimple sprang up; both seemed to contain clear fluid. Gradually the two fused into one larger mass, which slowly enlarged. After one month the swelling was opened by a doctor and a bloody fluid escaped, after which it slowly "dried up." In a few