The author, in the preface to the present edition, states that he has made many changes, particularly in the chapters on the chemistry of the urine, to keep abreast with recent advances. In general he has brought his book to a very high standard of excellence and utility. Still there are a few pages which might be improved on. For the determination of uric acid, for instance, the author recommends Heintz' method of precipitation by hydrochloric acid. This procedure, according to Salkowski, Naisch and others, is inaccurate. Besides, it requires a determination by weighing on fine chemical scales, which are almost never in the possession of the general practitioner. In a text-book for the use of the latter, it would undoubtedly be better to recommend and give in detail Arthand and Butte's method of titration with cuprous hyposulphite, with a 10 per cent, solution of potassium and anthoyenate as indicator.