Is carcinoma increasing in frequency? This question is now a subject of discussion. Roswell Park of Buffalo, Finkelnburg of Germany, and others have brought forward certain statistics which go to show that the mortality-rate for carcinoma is increasing. There is some doubt, however, as to the reliability of the figures available for this kind of study. Evidence has also been brought forward to show an increased frequency of the so-called endemic occurrence of carcinoma. Behla, Behrens, Pfeiffer, Arnaudet, Schuchardt and others have narrated apparently striking examples of small cancer centers in villages, parts and streets of cities and in single houses. According to Finkelnburg, there occurs in Prussia as a whole, 1 death from carcinoma in every 40 deaths; in Corneilles, in Normandy, Arnaudet and others have demonstrated the abnormally high relation of 1 carcinoma death to 7 from other causes; in a well circumscribed part of Luekan Behla shows