Harvey observed that in cases of general infection the advent of local suppuration was attended with amelioration of the constitutional symptoms. Fochier was, in 1891, led to induce suppuration artificially under like conditions; at first using for this purpose an acid solution of quinin sulphate, later 10 per cent. solution of silver nitrate, and finally, oil of turpentin given by injection beneath the skin. The results were entirely satisfactory. Numerous observers in different countries have employed this measure with equally satisfactory results in the treatment of such varied conditions as pyemia, septicemia, typhoid fever, erysipelas, osteomyelitis, scarlet fever, pneumonia, etc. Fochier originally thought that the artificially induced abscess attracted noxious matters, including bacteria, but the pus-collections were, as a rule, found to be sterile. Subsequently Chantemesse attributed the favorable results to a hyperleucocytosis, but he failed to find the number of white blood-corpuscles increased. By others it has been believed