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May 13, 1899, Vol XXXII, No. 19 >
ARTICLE | May 13, 1899

HYDROCEPHALUS AND HYPOPLASIA OF THE ADRENALS.

JAMA. 1899;XXXII(19):1064-1065. doi:10.1001/jama.1899.02450460048012.
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In the absence of any well-founded hypothesis as to the cause of hydrocephalus, and the futility of the examinations of the hydrocephalic brain for the purpose of explaining this condition, Czerny1 injected solutions of Berlin blue into the cerebral ventricle of young rats, and watched for the first place at which the solution emerged from the cerebrospinal canal. He observed that the color first appeared in a lymphvessel which sends a branch to the adrenals, and then leads to the lymph-glands of the pelvis. This led him to investigate the condition of the adrenals in hydrocephalus.

In five cases he found that the adrenals were macroscopically quite normal. Microscopically, however, he found to his great surprise, that in every case there was a complete absence of the so-called medulla of both adrenals. The cortical layers were separated from each other only by a few large veins. In order to

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