The present epidemic of smallpox in this Province may be said to be practically at an end. No new cases are appearing; all unprotected persons have been vaccinated, and all infected houses have been disinfected. We have isolated and treated in our isolation hospitals more than twelve hundred cases. These hospitals are located at convenient centers of inspection—Holguin, Gibara, Auras, Fray-Benito, Puerto Padre, Las Nuevas, La Caridad and Mayari, Their records show respectively, 475, 230, 210, 123, 50, 93, 15 and 5 cases. At the present time there are less than three hundred cases under treatment, most of which are convalescent. Our rate of mortality has been less than 12 per cent. We attribute this excellent result to open-air treatment and to bichlorid baths —every patient receiving daily baths in strong solutions (1 to 1000) of bichlorid of mercury. The openair treatment is a necessity in this locality, the open