During a recent epidemic of smallpox in this county, I was able to watch very closely this disease, which privilege is not accorded to the larger number of practitioners. The disease was confined wholly to the Mexican population—who as a rule are unprotected by vaccination—and made the greatest ravages among children under ten years. In some cases vaccination had been performed during early life; and in others more recently, and in the large majority of instances, never.
Several extraordinarily severe cases coming under my care, in whom vaccination has been successful, I was curious to note the outcome.
Sophia G., aged 15 years, was successfully vaccinated at an early age, scar being quite distinct and typic, and again six weeks previous to her illness. She was taken ill with smallpox, showing all the ordinary symptoms, except as regards pain in back, which was more severe than usual. The attack appeared