The existence of an intimate relationship between diseases of the female generative organs and morbid conditions and functional disorders in other parts of the body was known and appreciated in the earliest days of gynecology. The older gynecologists, guided as they were by clinical observations alone, and misled by a false pathology, based upon speculations and guesses, regarded these conditions and disorders as expressions of a mysterious, sympathetic or nervous influence that these organs, when diseased, exercised over remote parts of the body. For many years such obscure, vague and indefinite explanations satisfied the arm-chair theorist and furnished guidance and consolation to the office gynecologist and his patients. So long as our knowledge of pelvic disease was limited to conjectures suggested by the position of the uterus, the character of the vaginal discharge, the appearance of the os, etc., and our treatments were confined to applications, poultices, injections and sedatives,