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REVERSIBILITY OF ENZYMES, AND ITS APPLICATION TO PHYSIOLOGIC AND PATHOLOGIC PROCESSES.

H. GIDEON WELLS, M.D.
JAMA. 1902;XXXVIII(4):220-223. doi:10.1001/jama.1902.62480040006001b.
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Ordinary chemical reactions with which we are most familiar are usually considered as occurring in a very definite manner, the addition of one substance to another leading to the formation of one or more new substances. But it is also a fact that if the proper conditions are produced such a reaction can be made to take place in a reverse manner, the resulting substance or substances being made to yield the substances from which they were originally produced. Recent work has developed the fact that enzyme action is also capable of reversibility, so that when proper conditions exist the products of the hydrolytic splitting, if such has been the change, are reunited by the same enzyme that separated them into the original, more complex molecule. This newly observed property is probably destined to explain many important problems in physiology and pathology, and as so far the literature dealing with

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