JAMA. 1901;XXXVII(25):1681-1682. doi:10.1001/jama.1901.02470510037004.
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Views concerning the pathogenesis of exophthalmic goiter have undergone many changes. By some the disorder was considered a dyscrasia, due to impoverishment and deterioration of the blood. By others the symptoms were ascribed to alterations in the heart and the vascular system. Later, derangement of the nervous system— either the cervical sympathetic or the medulla—was held responsible for the condition, while recently the manifestations have been attributed to excessive functional activity of the thyroid gland, and, last of all, disease of certain glandular bodies designated parathyroid, two on each side of the thyroid gland, are accredited with etiologic significance. It appears that some functional relation exists between the thyroid gland and the parathyroid bodies. A number of experimental observations go to show that the removal of the latter gives rise to secretory and histologic changes in the former— consisting in disappearance of the colloid substance and hypertrophy of the gland—and


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