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JAMA. 1901;XXXVII(23):1533-1534. doi:10.1001/jama.1901.62470490031001j.
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Mestivier, in 1758, was the first to record a case of lesion of the appendix. Eight years later, in 1766, De La Motte refers to a case which he found on making an autopsy. Laennec, in 1803, by his studies on the peritoneum made some headway. But no one seemed to have remarked the significance of his discoveries. In 1824 Lonyer-Wildermay reported a fatal case of peritonitis and gave the perforation of the vermiform appendix as the cause. Husson and Dance, in 1827, gave a detailed description of the diseases of the cecum. Both Lonyer-Wildermay and Melier believed that the diseases of the cecum and appendix were separate and distinct. Melier, in 1827, reported four cases, three of which were perforations of the appendix with fulminating peritonitis. He considered the causes, character and consequences of appendicitis; he even anticipated the possible advantages of operation. He says: "If it were possible


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