JAMA. 1901;XXXVI(14):968-969. doi:10.1001/jama.1901.02470140038002.
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In the Middleton Goldsmith lecture before the New York Pathological Society, March 26, 1901, Minot discussed the relations between pathology and embryology.1 Embryology and pathology—more particularly pathological anatomy and histology—both deal with problems of development of anatomical forms; and naturally the laws of organization of normal structure must be of fundamental importance to the student of abnormal structure and function. Minot first discussed normal differentiation, beginning with the fertilized ovum, which, though a very complex organization, is an undifferentiated being with a protoplasm of apparently uniform structure, every part of which is capable of producing any or all of the tissues of the adult. During the process of differentiation each successive stage limits the range of possible change, and before long the potential fate of the cells is limited by the conditions of layership, as Minot terms the relations of the cells to the germ layers, the three distinct


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