An important monographic study of the bacteriology and the pathology of 220 fatal cases of diphtheria, by Councilman, Mallory, and Pearce, has just appeared as a number of the Journal of the Boston Society of Medical Sciences (1901, v, No. 5). As pointed out in the introduction, diphtheria may now be considered as the best known of any of the infectious diseases. The study devoted to this disease has "in a marked degree increased our knowledge of pathological anatomy, of bacteriology, and of therapeutic measures in infectious diseases. In no other disease has the discovery of the cause led to measures of prevention and of cure which have been rewarded by such brilliant success."
Diphtheria was first described definitely by Bretonneau in 1826. Now its literature has grown to enormous proportions. The development of the different phases of our knowledge of the disease—the pathological anatomy, the bacteriology, and the antitoxic