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March 16, 1901, Vol XXXVI, No. 11 >
ARTICLE | March 16, 1901

THE PHARMACOLOGIC ASSAY OF DRUGS AND ITS IMPORTANCE IN THERAPEUTICS.

E. M. HOUGHTON, M.D.
JAMA. 1901;XXXVI(11):727-729. doi:10.1001/jama.1901.52470110029002g.
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ABSTRACT

Note.  —The word "pharmacology" is employed as meaning "the study of the changes induced in living organisms by the administration in a state of minute division of such unorganized substances as do not act merely as foods."After a correct diagnosis has been made, one of the most important questions to be considered by the physician is that of dosage. Especially is this true when, as often occurs, the patient's life depends upon prompt and efficient aid. But if the drugs prescribed are not of fixed and definite strength our efforts may prove utterly unavailing.Until a few years ago we were obliged to employ pharmaceuticals of uncertain and varying strength. This variation was due not alone to differences in the process of manufacture, but also to the fact that the amount of active constituents contained in the crude drug itself varies from season to season, is modified by habitat,

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