JAMA. 1901;XXXVI(7):447-448. doi:10.1001/jama.1901.02470070033004.
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Lesions of the pituitary body have been found in so large a proportion of cases of akromegaly in which post-mortem examination has been made that, according to the prevailing view, the symptoms of the disease are to be attributed to such lesions, the pituitary body being believed to exercise some influence—of an inhibitory nature—on the growth and development of the skeleton, and the removal of which permits of hypertrophy of the bones. Some enlargement of the pituitary body has been observed also in cases of myxedema and cretinism; while, on the other hand, tumors of the pituitary body are sometimes unattended with symptoms of akromegaly and, as has been indicated, no change in the pituitary body has been noted in some cases of akromegaly, this body having been entirely wanting in at least one case. In many, further, the thyroid gland has been enlarged; and the thymus has been persistent


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