Dr. E. H. Squibb, of Brooklyn, in a reprint from the Transactions of the New York State Medical Association, 1891, entitled "The Materia Medica, Pharmacy and Therapeutics of the year ending October 1, 1891," emphasizes the warnings of a few writers against the indiscriminate use of sulphonal. He considers that it is usually safe; and having a wide range of usefulness, its sale has largely increased during the past year. The form of administration, in a very hot aqueous solution, as suggested by Dr. Stewart, of Philadelphia, is commended as a means of securing prompt action and of avoiding the customary delay of an hour or more. Dr. W. H. Gilbert, of Baden Baden, thinks he has seen undesirable results from its popular and steady use. "It is surely bad practice," writes Dr. Squibb, "to leave the matter in the patient's hands to the extent of directing him to take