JAMA. 1900;XXXV(16):1031-1032. doi:10.1001/jama.1900.02460420045005.
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Although but little more than a year has elapsed since Bier presented his first article on cocainization of the spinal cord as a means of inducing anesthesia for surgical purposes, he has also deemed it necessary to warn against the too free use of the drug in this manner.1

He considers the dose of 4 cgs. to 5 cgs., which has been used, as dangerous, and says the dose should not exceed 15 mgs. He holds the problem is not to use cocain in the manner which he first described, and for which he predicts no great future, but to devise means of rendering cocain harmless and to prevent its unpleasant after-effects or to discover some non-toxic substance. He has been working along these lines with some success, but says that all these experiments are not yet concluded, but that they still need to be worked out.

Lest the apparent


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