Tuberculocidin; or, Professor Klebs' Modification of Koch's Tuberculin.

Karl von Ruck, M.D.
JAMA. 1892;XVIII(5):143-144. doi:10.1001/jama.1892.02411090023009.
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To the Editor of the Journal of the American Medical Association: 

Sir:  —With a supply of this substance recently received by me from Prof. Klebs, he gives the following instructions as to its use and action: The beginning dose to be from two to five milligrams, and the increase to be rapid up to one, and subsequently to two, four, six, and eight centigrams.Hectic fever is no contra-indication; in fact, the temperature rapidly decreases and the local conditions improve.The preparation causes absolutely no fever in tubercular patients, and increasing fever when present is an indication for increasing doses.The remedy is given daily, and when large doses are reached they are divided, half being given in the morning and the other half in the evening.The disintegration of the bacilli becomes manifest after five to ten of the larger doses have been given. Cough and expectoration diminish and


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