JAMA. 1900;XXXV(13):830. doi:10.1001/jama.1900.02460390046009.
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The rose spots form an important diagnostic feature in typhoid fever. The cause of the cutaneous changes that present themselves as rose spots remained unexplained until a year ago, when Neufeld and Curschmann succeeded in cultivating typhoid bacilli from the blood in the spots, thus demonstrating that the roseola depends on the lodgment of the bacilli in the skin. But Neufeld did not succeed in demonstrating bacilli in sections of roseolous areas, and consequently a clear idea of the exact relations of the bacilli to the lesions in the skin could not be formed. E. Fraenkel,3 who was one of the first to show that the typhoid bacilli multiply rapidly after death and that the masses of bacilli found in properly stained sections of typhoid organs are largely of post-mortem origin, succeeded readily in finding bacilli in the rose spots after preservation of the excised pieces in bouillon at


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