JAMA. 1891;XVII(11):421-422. doi:10.1001/jama.1891.02410890039014.
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A writer in the Medical Press and Circular gives a caution regarding the very indiscriminate use to which sulphonal is frequently put even by the laity. This drug was introduced about three years ago as a perfectly safe soporific, and corroborative testimony of this hopeful candidate have been abundant. Latterly there have been a few contrary reports about the safety and efficacy of the remedy, and the size of the maximum or poisonous dose could not be unanimously agreed upon. We have not a few cases on record where about three tablespoonfuls have been taken to produce sleep; in one of these cases the sleeper slept the greater part of five days and a half without permanent injury to his nervous system. Another person took a dose about one-third smaller, but never reawakened. A more unusual and extreme case has recently been reported by Dr. Ernest Neisser. A chemist's


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