JAMA. 1898;XXX(13):721-723. doi:10.1001/jama.1898.72440650029001k.
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It is hard to say why tobacco has been selected as the general agent for inciting what is called toxic amblyopia. Is it not a fact that various toxic agents are said to be attended by varying degrees of amblyopia, and that some writers, apparently eager to ignore the effects of alcohol, have taken up the consideration of central and peripheral lesions of the optic nerve, clearly due to prolonged local disturbances of the vasomotor system, from various kinds of excesses and mechanical obstruction to nutrition, even including tuberculosis, to set forth an exaggerated view of the by no means well-established toxic effect of tobacco?

In Turkey where tobacco is inordinately used by both sexes and among all classes, the so-called tobacco amblyopia, according to competent observers, is almost unknown, and yet the daily consumption of tobacco by this portion of the Mussulmanic race is enormous. Carefully made assays show


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