Charlotte, N. C., March 7, 1898.
To the Editor:
—In your remarks under the above heading, in the issue of March 5, 1898 (page 561), you make some statements which appear to deserve some qualification, at least from my information and experience on the subject. That there is a form of malaria (the disease) which resists the. therapeutic action of quinin even when in proper dosage by the stomach, rectum and skin, is within the experience of a number of physicians throughout the South. This form of malaria, designated the estivo-autumnal, will not infrequently persist in spite of the exhibition of large and repeated doses of quinin, the patient dying literally saturated with the drug and thoroughly cinchonized. Dr. Osler, the highly gifted and capable authority quoted to support the points of the editorial, has given absolute testimony to the fact that quinin will not remove the crescentic forms from