JAMA. 1891;XVI(12):409-412. doi:10.1001/jama.1891.02410640013002.
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Therapeutics and Pharmacology. 

Koch's Treatment of Tuberculosis: General Results.  Dr. J. Amann, of Davos, says (Centralbl. f. Bakteriologie u. Parasitenk., No. I, Band ix, January, 1891), that since November 17, there have been in Davos 400 cases of phthisis treated by Koch's method. Of 288 patients whose sputum he examined, 198 have been so treated. He examined the sputum of these latter sometimes once a day, sometimes once every two, three, or six days. He comes to the conclusion that the treatment has a most marked effect on the tuberculous tissues of the lung, and gives the following points of evidence in favor of this statement: The quantity of expectoration after the inoculation reaction is, as a rule, increased, in one case from 30 cubic centimetres to 140 cubic centimetres per diem. The number of tubercle bacilli in the sputum is also increased, in some cases the bacilli becoming


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