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MEDICAL PROGRESS.

JAMA. 1891;XVI(8):270-272. doi:10.1001/jama.1891.02410600018003.
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ABSTRACT

Therapeutics and Pharmacology. 

A New Mode of Exhibiting Sulphonal.  Dr. David D. Stewart, of Philadelphia (Medical News), says that unquestionably the great disadvantage of sulphonal over other recently-introduced hypnotics is its insolubility and consequent slowness of action. As ordinarily administered, dry upon the tongue, or suspended in mucilage, etc., the result, in most cases, is unsatisfactory. Even after a decided dose hours often elapse before sleep is obtained, and, usually, a condition of very annoying semi-somnolence is maintained throughout the greater part of the subsequent day. Unpleasant effects of this sort are so frequent that many physicians are deterred from prescribing what has proved in my hands the most satisfactory of the newer hypnotics. These effects obtain because of the very slow diffusion of the drug when taken in a state of simple suspension, the whole amount not entering the circulation for many hours after its ingestion.I desire

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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