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JAMA. 1891;XVI(8):270-272. doi:10.1001/jama.1891.02410600018003.
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Therapeutics and Pharmacology. 

A New Mode of Exhibiting Sulphonal.  Dr. David D. Stewart, of Philadelphia (Medical News), says that unquestionably the great disadvantage of sulphonal over other recently-introduced hypnotics is its insolubility and consequent slowness of action. As ordinarily administered, dry upon the tongue, or suspended in mucilage, etc., the result, in most cases, is unsatisfactory. Even after a decided dose hours often elapse before sleep is obtained, and, usually, a condition of very annoying semi-somnolence is maintained throughout the greater part of the subsequent day. Unpleasant effects of this sort are so frequent that many physicians are deterred from prescribing what has proved in my hands the most satisfactory of the newer hypnotics. These effects obtain because of the very slow diffusion of the drug when taken in a state of simple suspension, the whole amount not entering the circulation for many hours after its ingestion.I desire


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