Special Article.

JAMA. 1905;XLIV(11):873-874. doi:10.1001/jama.1905.02500380037002.
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TOXINS AND ANTITOXINS.  There is a large class of organisms which apparently produces no soluble toxin; such organisms, however, cause highly toxic diseases (e. g., typhoid, cholera, Intracellular plague). The dead or ground-up bodies of Toxins, or such bacteria are very toxic; also when the Endotoxins. germs disintegrate by a process of autolysis or self-digestion the culture medium becomes toxic because of the cell contents which are set free. Such organisms are said to contain intracellular toxins or endotoxins. In infections by them it has been supposed that toxic symptoms are produced when a sufficient number of the bacteria become dissolved through the action of the body fluids or some of the cells (phagocytes), the intracellular toxins being thus liberated. Nothing is known of the nature of such toxins. They certainly are very different from the soluble toxins of diphtheria and tetanus, since immunization with them has


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