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Clinical Report.

JAMA. 1905;XLIV(8):627-629. doi:10.1001/jama.1905.02500350037003.
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A CASE OF ARTHRITIS DEFORMANS IN WHICH LARGE DOSES OF ARSENIC WERE TAKEN.*  DUNCAN L. ALEXANDER, M.D.Interne, University Hospital.ANN ARBOR, MICH.

Patient.  —A. M., aged 24, single, farmer, American; was admitted to the medical clinic of the University Hospital, Oct. 29, 1901. Patient complained of dull, heavy pain, stiffness and deformity of many joints. Family history negative. Previous history negative. Diphtheria at 6, measles at 15. Denies venereal disease.

History.  —The present disease began six years ago with a dull, heavy pain, swelling and grating on movement of the left knee. The same condition manifested itself in the left hip, left elbow and wrist, in rapid succession. Two years ago, the temporo-maxillary joints became stiff, with a click on movement and much swelling over the glenoid fossæ. At the same time there was stiffness of the neck; soreness, and pain on swallowing, in the

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