Special Article.IMMUNITY.

JAMA. 1905;XLIV(8):625-627. doi:10.1001/jama.1905.02500350035002.
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NATURAL IMMUNITY: (A) PROTECTION OF THE BODY SURFACES; (B) THE RÔLE OF INFLAMMATION.  (A) Virulent organism (e. g., staphylococci and streptococci) exist normally on the skin or between the superficial horny cells, some exceptional circumstance being necessary to enable them to penetrate deeper and to cause disease (wounds). It is evident, then, that the physiologic shedding of the superficial horny cells and their continual reformation at a deeper level is a process calculated to rid the surface of the body of many micro-organisms.The question whether micro-organisms can ever penetrate the unbroken skin has been much discussed. Although experiments have shown that traumatism is not absolutely necessary, clinical experience indicates that these so-called cryptogenetic infections are not of ready occurrence. When they do occur, the infection atrium is probably one of the glandular orifices.Soluble poisons such as aconite and bacterial toxins are not absorbed through the unbroken skin.


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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