In a recent number of the Archives de Médecine Expérimentale, Dr. Melassez gives the history of his discovery of psorospermes in map, and especially in epithelioma. In 1885 Dr. Albarran brought an epithelial cancer, removed from the maxilla, for examination. The coccidia were found in the preparation, but as the neoplasm was ulcerated, they might have been introduced secondarily. Subsequently, in 1889, Dr. Darier gave him sections from an obscure cutaneous affection (Paget's disease), in which protoplasmic masses were found in the interior of the epithelial cells. These psorospermes, analogous to those found in the liver of the hare, were also found in old sections of epithelioma and of acne varioliformis. These discoveries were reported at the time, and subsequently Wickham found the psorospermes in a nasal epithelioma, and Cornil, Darier, Thoma and Sjöbring have published observations confirming the discovery of these organisms in epithelioma from various localities.