JAMA. 1898;XXX(4):177-180. doi:10.1001/jama.1898.72440560005001a.
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I have present today several well marked examples of constitutional syphilis. I bring them before you not because they are rare types, but because they collectively represent some of the most characteristic phases of the disease.

MACULAR SYPHILIDE.  This young man, 22 years of age, contracted a chancre three months ago. The period of incubation was sixteen days and the lesion lasted three weeks. Nine weeks and a half after inoculation, having regarded himself in the meantime as entirely well, he noticed that his hair came out when he used the brush. He also found a few small scattered papules upon his scalp. The hair has continued to fall and is now quite thin. The papules are of a coppery color. Upon his back and sides I observed what the patient had not yet detected, viz., a macular eruption. There have been no osteocopes or noticeable fever. His throat has


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