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JAMA. 1905;XLIV(4):299-300. doi:10.1001/jama.1905.02500310043007.
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It has been seen how the hypothesis that uric-acid formation is due to an oxidation of albumin, which stops short of urea, gradually came to be discredited. The keen Salkowski, in 1870, had pointed out that if the uric acid in leukemia is due to faulty oxidation, other incomplete oxidation products must also be present. Those most likely to occur would be oxalic acid and allantoin, but careful studies of the urine in leukemia revealed no increase in these compounds. Salkowski, in 1871, therefore rejected Bartels' conception and inclined to view with favor Ranke's hypothesis that uric acid is derived from xanthin bases and the spleen. Against this was the observation that xanthin bases appeared to occur in only very minute quantities in the tissues, and, further, that feeding experiments made with xanthin on dogs (an unsuitable animal, as will be seen) caused no increase in uric-acid excretion.



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